The NFL is off to a blazing start. It has set league records for the most touchdowns (281), offensive touchdowns (273), completions (2,259), touchdown passes (172) and points (2,446) through the first three weeks on any season.

But it looks like maintaining the pace might be tough for a few teams that continue to deal with injuries as we continue with Week 4 on Sunday.

Goedert’s Injury Could Ground Eagles

This is a critical week for the Philadelphia Eagles. They come to San Francisco 0-2-1, a legitimate six-point underdog. Worse yet, it could be a transitional week at quarterback with the cries to replace Carson Wentz with Jalen Hurts growing louder.

The big problem for the Eagles will be their lack of offensive weapons. Already without most of their first-tier receivers, the team has now lost tight end Dallas Goedert for a few weeks with an ankle injury. Goedert entered last week leading the Eagles in targets, receptions and receiving yards.

On Friday, the Eagles announced that receivers DeSean Jackson (hamstring) and Alshon Jeffrey (foot) are out and JJ Arcega-Whiteside (calf) is doubtful. Jalen Reagor (thumb) is already on IR.

Cardinals May Be Without Hopkins

The acquisition of receiver DeAndre Hopkins in a trade with Houston has widely been hailed as the steal of the offseason. He has meshed so well with Kyler Murray that the Cardinals have become a really interesting team to watch. But the Cardinals’ star receiver did not practice for the second consecutive day Thursday because of an ankle injury and was not on the field during the part of practice media was allowed to observe on Friday. He currently leads the NFL in receptions (32) and yards (356). The Cardinals are going to leave it up to him to decide if he plays against Carolina.

Some high-profile receivers who have missed games with injuries this season may be back this weekend. San Francisco tight end George Kittle, who injured his knee in Week 1 against Arizona, has been cleared to play against the Eagles. Green Bay’s Davante Adams practiced Friday and will likely return against Atlanta, which should welcome back Julio Jones from his hamstring injury. Jones also practiced on Friday. Jacksonville’s D.J. Chark has been cleared to make his return and Will Fuller is expected back for Houston’s game against Minnesota.

Meanwhile, Michael Thomas (ankle) returned to practice on a limited basis for the Saints but will not play at Detroit. The same is true for Saints tight end Jared Cook. Atlanta’s Calvin Ridley practiced Friday but remains questionable for the Packers. Chris Godwin (hamstring) will miss multiple weeks in Tampa Bay and slot receiver Scotty Miller (hip, groin) did not practice this week. Mike Williams of the Chargers is out (hamstring) after missing practice all week. Raiders rookie Henry Ruggs (hamstring) is doubtful. And Allen Lazard, who caught six passes for 146 yards filling in for Adams in last week’s win for the Packers, is out six-to-eight weeks after core surgery.

Adams Out For Surging Seahawks

Seattle is a seven-point favorite at Miami this week, based largely on the MVP start Russell Wilson (14 TD passes, 139.0 passer rating) has had. But injuries are really starting to pile up. On Wednesday, there were 12 players listed on the NFL’s injury report. Most notably, the Seahawks will be without safety Jamal Adams (groin) and might without running back Chris Carson (knee), both of whom were injured in last week’s win over the Cowboys. Carlos Hyde, who would have replaced Carson, is questionable with a shoulder injury.

Around The League

QB Jimmy Garoppolo (ankle) and running back Raheem Mostert (knee) are out for the 49ers game against the Eagles. Defensive end Dee Ford (neck) is on IR until Week 7 and tight end Jordan Reed (knee) may be out two months. We still like them over the Eagles. … If the Falcons manage to stay close to the Packers, missing kicker Younghoe Koo (groin) could hurt them. And Jacksonville’s kicking situation is also a mess. Josh Lambo (hip), Brandon Wright and Stephen Hauschka (knee) are injured. They’ve signed Aldrick Rosas as insurance if Hauschka can’t go at Cincinnati. … Kansas City lost safety L’Jarius Sneed (collarbone) last Monday night against Baltimore. More importantly, defensive end Chris Jones (groin) is questionable against New England. That might jeopardize the Chiefs’ status as seven-point favorites.

Las Vegas rookie receiver Henry Ruggs III (knee) is doubtful for Sunday’s home game against Buffalo and Chargers star defensive end Joey Bosa (triceps) is questionable for the Tampa Bay game, even though he’s played the last two weeks with it. With cornerback Chris Harris (ankle) out for two months, the lack of a pass rush could be deadly against Tom Brady. …Redskins rookie defensive end Chase Young, the second overall pick, is doubtful against the Ravens (groin) and defensive tackle Matt Ioannidis (biceps) is out for the season. You might want to consider investing in the Ravens, even as a 13 ½-point favorite. …The Bears will begin to make the adjustment to life without running back Tarik Cohen, lost for the season last week with an ACL injury. That won’t help the Bears as a three-point dog to the Colts. …Tampa RB Leonard Fournette (knee) will not play on Sunday